Organic Letters
Letter
(13) Plaza, A.; Viehrig, K.; Garcia, R.; Mu
̈
ller, R. Jahnellamides, α-
ASSOCIATED CONTENT
* Supporting Information
The Supporting Information is available free of charge on the
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Keto-β-Methionine-Containing Peptides from the Terrestrial Myx-
obacterium Jahnella sp.: Structure and Biosynthesis. Org. Lett. 2013,
15, 5882−5885.
S
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carbinol carbons. Nat. Protoc. 2007, 2, 2451−8.
1
Experimental details, H and 13C assignments, MS and
MS2 data, Marfey’s and feeding results, in silico analysis,
and one- and two-dimensional NMR spectra (PDF)
(16) Matsumori, N.; Kaneno, D.; Murata, M.; Nakamura, H.;
Tachibana, K. Stereochemical Determination of Acyclic Structures
Based on Carbon-Proton Spin-Coupling Constants. A Method of
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AUTHOR INFORMATION
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Corresponding Author
ORCID
(17) Blin, K.; Weber, T.; Kim, H. U.; Lee, S. Y.; Medema, M. H.;
Duddela, S.; Krug, D.; Muller, R.; Bruccoleri, R.; Fischbach, M. A.;
̈
̈
Author Contributions
§E.O. and T.K. contributed equally to this work.
Wohlleben, W.; Takano, E.; Breitling, R. antiSMASH 3.0a
comprehensive resource for the genome mining of biosynthetic
gene clusters. Nucleic Acids Res. 2015, 43, W237−W243.
(18) Yadav, G.; Gokhale, R. S.; Mohanty, D. Computational
approach for prediction of domain organization and substrate
specificity of modular polyketide synthases. J. Mol. Biol. 2003, 328,
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Notes
The authors declare no competing financial interest.
(19) Stachelhaus, T.; Mootz, H. D.; Marahiel, M. A. The specificity-
conferring code of adenylation domains in nonribosomal peptide
synthetases. Chem. Biol. 1999, 6, 493−505.
(20) Kelley, L. A.; Mezulis, S.; Yates, C. M.; Wass, M. N.; Sternberg,
M. J. E. The Phyre2 web portal for protein modeling, prediction and
analysis. Nat. Protoc. 2015, 10, 845−858.
(21) Cura, V.; Marechal, N.; Troffer-Charlier, N.; Strub, J. M.; van
Haren, M. J.; Martin, N. I.; Cianferani, S.; Bonnefond, L.; Cavarelli, J.
Structural studies of protein arginine methyltransferase 2 reveal its
interactions with potential substrates and inhibitors. FEBS J. 2017,
284, 77−96.
(22) Ansari, M. Z.; Sharma, J.; Gokhale, R. S.; Mohanty, D. In silico
analysis of methyltransferase domains involved in biosynthesis of
secondary metabolites. BMC Bioinf. 2008, 9, 454.
ACKNOWLEDGMENTS
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The authors thank HIPS colleagues Dr. K. Harmrolfs and Dr.
L. Keller for NMR advice, Mr. J. Hug, Mr. F. Panter, and Mr.
B. Schnell for insightful discussions, and Ms. V. Schmidt and
Dr. J. Hermann for bioassays. This work was funded by the
German Centre for Infection Research (DZIF).
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be used in this paper.
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