Journal of Coordination Chemistry p. 3160 - 3173 (2012)
Update date:2022-08-17
Topics:
Ma, Lili
Zhang, Jinchao
Zhang, Fangfang
Chen, Chao
Li, Luwei
Wang, Shuxiang
Li, Shenghui
Eight new palladium(II) complexes with 4-toluenesulfonyl-L-amino acid dianion and 1,4-dab/1,3-dap, [Pd(1,4-dab)(TsglyNO)]H2O (1), [Pd(1,4-dab)(TsvalNO)] (2), [Pd(1,4-dab)(TsleuNO)] (3), [Pd(1,4-dab)(TsileNO)] (4), [Pd(1,4-dab)(TsserNO)]0.5H2O (5), [Pd(1,4-dab)(TspheNO)]0. 5H2O (6), [Pd(1,4-dab)(TsthrNO)]H2O (7), and [Pd(1,3-dap)(TsserNO)] (8), have been synthesized and characterized by elemental analysis, IR, UV, 1H NMR, and mass spectrometry. Crystal structure of 8 has been determined by X-ray diffraction. The cytotoxicities were tested by MTT assay. The results indicate the complexes exert cytotoxic effects against HL-60 and Bel-7402. The structure-activity relationship suggests that both amino acids and N-containing ligands have important effects on cytotoxicity, but the IC50 values do not show definite correlation with variation of these ligands.
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