The chemistry of N,N-bis(trialkylsilyloxy)enamines 2. Alkylation of primary amines with N,N-bis(trimethylsilyloxy)enamines

Article abstract of DOI:10.1007/bf02495772

The reactions of primary amines with N,N-bis(trimethylsilyloxy)enamines can give products of both mono- and bis-α-oximinoalkylation of primary amines. The steric restrictions in both reactants substantially retard bis-α-oximinoalkylation. A general method for the synthesis of α-amino-substituted oximes from primary amines and bis-silyl derivatives of aliphatic nitro compounds was developed.