13647-35-3

Usage

InChI:InChI=1/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1

Upstream product

• 20051-76-7 4α,5-epoxy-(5α)-androstano[2,3-d]isoxazol-17β-ol 

Related news

The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor Trilostane (cas 13647-35-3) in mice is related to changes in neuroactive steroid and monoamine levels09/24/2019

In the present study, we analyzed the effects of a systemic treatment with the competitive 3β-hydroxysteroid dehydrogenase (3β-HSD) inhibitor trilostane on: (i) neurosteroid and monoamine levels in the brain, and (ii) the antidepressant activity of steroids and antidepressants in the forced sw...detailed

Possible Therapeutic Effect of Trilostane (cas 13647-35-3) in Rodent Models of Inflammation and Nociception09/08/2019

BackgroundTrilostane was identified in an in vivo screen of compounds in a lipopolysaccharide model of inflammation to support a repurposing effort. There is no previous documentation of any anti-inflammatory effects of trilostane.detailed

Short CommunicationStability of compounded Trilostane (cas 13647-35-3) suspension in cod liver oil09/06/2019

Trilostane is a synthetic steroid analog used to treat canine hyperadrenocorticism. For small dogs, the dose found in commercially available dosage forms of trilostane is sometimes too high. Compounding trilostane in a liquid diluent provides an option for more precise dosing and adjustments, an...detailed

Relevant academic research and scientific papers

METHOD FOR THE PREPARATION OF TRILOSTANE

The present invention relates to a method for the preparation of trilostane from (4α,5α,17β)-4,5-epoxyandrost-2-eno(2,3-d)isoxazol-17-o1 as a precursor compound, the method comprising the steps of a) dissolving the precursor compound in methanol; b) treating the precursor compound with a base to effect cleavage of the (2,3-d) isoxazole ring of the precursor compound; c) adding acid and water to the product of step b) to obtain a precipitate of Trilostanc; and d) isolating the precipitate of Trilostane.