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ARTICLE
Journal Name
P. The species Q is generated when base abstract the benzylic
proton from the species P which is stabilized by an aromatic ring.
The resulted benzylic anion attacks on electrophilic carbonyl carbon
and generates unstable species R. Finally, to attain the aromaticity
R loses a water molecule under basic condition and gave the
desired products 3, 4 or 5.
DOI: 10.1039/C9CC03689J
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Scheme 7. Proposed mechanism
Conclusions
In summary, the chemistry described herein provides a facile, atom-
economical, inexpensive and general approach for the synthesis of
highly decorated medicinally-useful isoquinolines in good to
excellent yields under transition-metal-free condition. The
challanging, bis-isoquinolines and 3-alkynyl/alkenyl isoquinolines
were also achieved in good to excellent yields. Developed strategy
tolerates variety of functional groups such as cyano, ester, amine,
alkyne, alkene and halides. From a synthetic point of view the net
transformation involves a one-pot conversion of simple and readily
available starting material into an interesting class of isoquinolines.
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Conflicts of interest
The authors declare no conflicts.
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Acknowledgments
The Research work was supported by SERB (EMR/2017/003218/OC)
and University of Delhi. and P. K. M and S.V., M. K., A. K., are
thankful to UGC and CSIR for fellowship, respectively.
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4 | J. Name., 2012, 00, 1-3
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