Heterocycles p. 2369 - 2384 (2013)
Update date:2022-08-28
Topics:
Sakakibara, Norikazu
Tsukamoto, Ikuko
Isono, Yohei
Takata, Maki
Konishi, Ryoji
Kato, Yoshihisa
Maruyama, Tokumi
We developed a novel pathway for the successful synthesis of leteprinim potassium 1, which is one of the candidate substances for treating Alzheimer's disease, and subsequently synthesized 4 types of corresponding novel derivatives 2-5 that have hypoxanthine or 2-chloro-6-aminopurine as the nucleobase. We then determined the angiogenic activity of these compounds by using human umbilical vein endothelial cells. Compounds 1-4 showed no angiogenic potencies judging from statistical analysis, student's t-test.
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