4
Scheme 5. Plausible Reaction Mechanism
Soc. 2015;137:2480-2483;
(n) Neumann KT, Lindhardt AT, Bang-Andersen B, Skrydstrup T. Org.
Lett. 2015;17:2094-2097;
(o) Shi R, Zhang H, Lu L, Gan P, Sha Y, Zhang H, Liu Q, Beller
M, Lei A. Chem. Commun. 2015;51:3247-3250;
(p) H. Yu, G. Zhang, H. Huang, Angew. Chem. Int. Ed. 2015;54:10912-
10916;
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Conclusion
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Soc. 2011;133:18114-18117.
In summary, we have developed an efficient method for the
first addition reaction of carbamoysilane to isatins. Moreover, the
reaction could undergo a one-pot synthesis process to furnish 3-
hydroxy-3-aminocarbonyl-2-oxindole with gram-scale. The mild
and no catalyst conditions, simple procedure and excellent yield
provide a valuable method for the preparation of various 3-
hydroxy-3-aminocarbonyl-2-oxindoles core structures. Further
studies on the applications of carbamoylsilanes are ongoing in
our lab.
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Acknowledgments
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We are grateful for the grants from Shanxi Normal University
of China (No. 2R1516050602080102).
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Supplementary data
Supplementary data associated with this article can be found,
in the online version, at http://dx.doi.org/10.1016/XXXX.
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