Highly Enantioselective Synthesis of β-Hydroxy Nitriles by the Cyanomethylation of Aldehydes using DPMPM as a Chiral Catalyst or Ligand

Article abstract of DOI:10.1016/S0957-4166(00)80498-X

Optically active β-hydroxy nitriles in up to 93percent e.e. were obtained by the enantioselective addition of cyanomethylzinc bromide to aldehydes using DPMPM as a chiral catalyst or ligand.