Structures and Reactivities of New Dolabellane Diterpenoids from the Caribbean Gorgonian Eunicea laciniata

Article abstract of DOI:10.1021/jo00010a039

Five new diterpenoids of the dolabellane class (3-7) have been isolated from the Caribbean gorgonian Eunicea laciniata Duchassaing and Michelotti.The structures of these metabolites were defined by combined spectra and chemical methods.The conformation and reactivity of the 11-membered ring of the dolabellanes was investigated by 1H NMR nuclear Overhauser enhancement difference spectroscopy (NOEDS) and by selected chemical transformations involving transannular cyclizations.