The synthesis of DL-3,3-difluoroglutamic acid from a 3-oxoprolinol derivative

Article abstract of DOI:10.1016/S0040-4039(00)74045-7

DL-3,3-Difluoroglutamic acid was synthesized from a masked 3-hydroxyprolinol, 6-hydroxy-1-aza-3-oxabicyclo[3,3,0]octan-2-one, in eight steps. The described synthetic route expands the utility of fluoroproline derivatives as precursors of fluoroglutamic acids.