A convenient synthesis of the paclitaxel side-chain via a diastereoselective Staudinger reaction

Article abstract of DOI:10.1016/S0040-4039(98)00548-6

The N-benzylidene dexivative of (S)-(-)-1-(p-mathoxyphenyl)propyl-1- amine, obtained by a new resolution procedure, exhibits moderate selectivity in the reaction with 2-acetoxyketene; the (S)-(-)-1-(p-methoxyphenyl)propyl group can be oxidatively cleaved from the resultant β-lactam, an important precursor for taxane semi-synthesis.