Tetrahedron Letters p. 1867 - 1870 (1991)
Update date:2022-08-29
Topics:
DeCamp, Ann E.
Kawaguchi, Alan T.
Volante, R. P.
Shinkai, Ichiro
A highly efficient route is presented for preparation of the medicinally important hydroxyester and lactone intermediates 1 and 2 from chiral α-amino aldehydes via homoenolate methodology.Several reaction variables were found to influence the ratio of che
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