(5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one

Base Information

• Chemical Name: (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one
• CAS No.: 133148-55-7
• Molecular Formula: C₂₆H₂₇NO₂
• Molecular Weight: 385.506

Synonyms:(5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one

Chemical Property of (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one

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Technology Process of (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one

There total 9 articles about (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

(2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1) + (1S,2R)-N-methylephedrinyl acrylate (187600-79-9) → (5S,1'S)-5-(1'-(dibenzylamino)-2'-phenylethyl)dihydrofuran-2(3H)-one (143337-98-8) + (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one (133148-55-7)

Guidance literature:

With samarium diiodide; tert-butyl alcohol; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jo020574h

Reference yield:

(2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1) + (1R,2S)-N-methylephedrinyl acrylate (52253-57-3) → (5S,1'S)-5-(1'-(dibenzylamino)-2'-phenylethyl)dihydrofuran-2(3H)-one (143337-98-8) + (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one (133148-55-7)

Guidance literature:

With samarium diiodide; tert-butyl alcohol; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jo020574h

Reference yield:

(2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1) + ethyl acrylate (140-88-5,9003-32-1) → (5S,1'S)-5-(1'-(dibenzylamino)-2'-phenylethyl)dihydrofuran-2(3H)-one (143337-98-8) + (5R)-5-<(1S)-1-(N,N-Dibenzylamino)-2-phenylethyl>-dihydrofuran-2(3H)-one (133148-55-7)

Guidance literature:

With samarium diiodide; tert-butyl alcohol; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jo020574h

upstream raw materials:

(2S)-N,N-dibenzylphenylalaninal

(1R,2S)-N-methylephedrinyl acrylate

(1S,2R)-N-methylephedrinyl acrylate

ethyl acrylate

Downstream raw materials:

(3R,5R)-3-Benzyl-5-((S)-1-dibenzylamino-2-phenyl-ethyl)-dihydro-furan-2-one

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