Steroids p. 221 - 225 (1997)
Update date:2022-08-22
Topics:
Reeder, Anthony Y.
Joannou, George E.
We report the synthesis of 10 novel steroids obtained from 3β,15β- diacetoxy-17α-hydroxy-5-pregnen-20-one (1c) as intermediates in the synthesis of 15β-acetoxy-20,20-ethylenedioxy-17α-hydroxy-4-pregnen-3-one (6a) and its tritiated tracer 15β-acetoxy-20-20-ethylenedioxy-17α-hydroxy- 1,2,6,7-3-pregn-4-en-3-one (6d). The one pot interconversion of intermediate (6a) to 3β,15β,17α-trihydroxy-5-pregnen-20-one (1a) and 3α,15β,17α- trihydroxy-5β-pregnan-20-one (2a) provides a new and efficient approach to the synthesis of diagnostically important metabolites of the human neonate and a possible route in the synthesis of the tritated tracers 3β,15β,17α- trihydroxy-1,2,7-3H-pregn-5-en-20-one (1d) and 3α,15β,17α-trihydroxy- 1,2,6,7-3H-5β-pregnan-20-one (2b) for the development of new immunoassays. We also report in this investigation an alternative route in the synthesis of 15β,17α-dihydroxy-4-pregnen-3,20-dione (7a) an intermediate in the synthesis of human 15β-hydroxysteroid metabolites.
View MoreChuzhou Baiao Biologhy S&T Co., Ltd.
Contact:+86-25-83212599;+86-25-83212699 13705185959
Address:Room 905, Tianzheng International Platza, No.399, Zhongyang Road ,Nanjing, Jiangsu Province, China
Jiangsu Zenji Pharmaceuticals LTD
Contact:+86-025-83172562; +1-224-888-1133(USA)
Address:No.5 Xinmofan Road
SINO Industries Company Limited
Contact:86-29-85369724
Address:No.111, Jiefang Road, Xi’an, China
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Contact:86-21-50966856
Address:Building 5,300 Chuanzhan Road,Pudong New District,Shanghai
Doi:10.1016/S0039-128X(83)90060-0
(1983)Doi:10.1039/c39740000291
(1974)Doi:10.1021/acs.orglett.7b00894
(2017)Doi:10.1002/ijch.202000082
(2021)Doi:10.1039/c7cc07347j
(2017)Doi:10.1039/c4ra12355g
(2015)