15250-41-6

Basic information

• Product Name: (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid
• Synonyms: (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid;(+)-1,2-Diaminopropanetetraacetic acid;(S)-(+)-1,2-propanediaminetetraacetic acid
• CAS NO: 15250-41-6
• Molecular Formula: C₁₁H₁₈N₂O₈
• Molecular Weight: 306.269
• Mol File: 15250-41-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 604.871 °C at 760 mmHg
• Flash Point: 319.615 °C
• Appearance: /
• Density: 1.505
• Vapor Pressure: 3.44E-16mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.80±0.10(Predicted)
• CAS DataBase Reference: (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid(15250-41-6)
• EPA Substance Registry System: (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid(15250-41-6)

Safety Data

• Hazardous Substances Data: 15250-41-6(Hazardous Substances Data)

Usage

Uses

Dabigatran etexilate intermediate

InChI:InChI=1/C11H18N2O8/c1-7(13(5-10(18)19)6-11(20)21)2-12(3-8(14)15)4-9(16)17/h7H,2-6H2,1H3,(H,14,15)(H,16,17)(H,18,19)(H,20,21)/t7-/m0/s1

Upstream product

• 19777-66-3 (S)-propane-1,2-diamine dihydrochloride 
• 79-11-8 chloroacetic acid 
• 67-56-1 methanol 
• 15967-72-3 (S)-1,2-diaminopropane 

Downstream Products

• 24584-09-6 dexrazoxane 

Relevant articles and documents

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Dexrazoxane preparation method

The invention belongs to the field of drug synthesis, and provides a completely-new dexrazoxane preparation method, which comprises: carrying out a reaction on (S)-1,2-propanediamine ditartrate splitby using inexpensive and easily-available (+/-)-1,2-propanediamine as a starting raw material and using D-(-)-tartaric acid as a splitting agent and potassium chloride to obtain (S)-1,2-propanediaminedihydrochloride, carrying out condensation on the (S)-1,2-propanediamine dihydrochloride and chloroacetic acid to prepare (S)-N,N,N',N'-1,2-propanediaminetetraacetic acid, and finally carrying out cyclization to obtain dexrazoxane, wherein the total yield is 38.3%. According to the present invention, the route has advantages of simple reaction step, convenient post-treatment, no requirement of column chromatography separation, good product quality and the like.