Monatshefte fur Chemie p. 1229 - 1240 (1994)
Update date:2022-08-11
Topics:
Marton, J.
Hosztafi, S.
Berenyi, S.
Simon, C.
Makleit, S.
Dihydronorthevinone (2b) was prepared from dihydrothevinone (2a) with diethyl azodicarboxylate (DEAD) and transformed into a number of new N-substituted dihydronorthevinone derivatives (2c-2g).Grignard reactions of the new compounds with methylmagnesium iodide and tert-butyl-magnesium chloride were studied.O-Demethylation of 3a-3j resulted in the corresponding N-substituted buprenorphine and diprenorphine analogs 4a-4j. - Keywords: Buprenorphine; Diprenorphine; Dihydronorthevinone; N-Substituted Dihydronorthevinone; Grignard-reactions; Morphine alkaloids; O-Demethylation with DIBAL.
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