136232-95-6

Basic information

• Product Name: buprenorphine hydrochloride
• Synonyms: 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, hydrochloride, [5β,6β,7β(R),9α,13α,14β]-
• CAS NO: 136232-95-6
• Molecular Formula: C29H42ClNO4
• Molecular Weight: 504.11
• Mol File: 136232-95-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: buprenorphine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: buprenorphine hydrochloride(136232-95-6)
• EPA Substance Registry System: buprenorphine hydrochloride(136232-95-6)

Safety Data

• Hazardous Substances Data: 136232-95-6(Hazardous Substances Data)

Usage

General Description

Buprenorphine hydrochloride is a semi-synthetic opioid medication used in the treatment of opioid addiction and chronic pain. It works by binding to and activating opioid receptors in the brain, producing analgesic and euphoric effects that help to reduce cravings and withdrawal symptoms in individuals with opioid dependence. Buprenorphine hydrochloride is a partial agonist, meaning it has a ceiling effect on respiratory depression and is less likely to cause overdose compared to full agonist opioids. It is typically administered sublingually as a tablet or film, and its long duration of action allows for once-daily dosing, making it an effective and convenient treatment option for opioid use disorder.

Upstream product

• 1489-69-6 Cyclopropanecarboxaldehyde 
• 78715-23-8 norbuprenorphine 
• 16196-82-0 7-acetyl-6,14-endo-ethano-6,7,8,14-tetrahydrothebaine 
• 15358-22-2 thevinone 
• 115-37-7 thebaine 
• 152427-77-5 (5R,6R,7S,9R,13S,14S)-7-Acetyl-17-cyclopropylmethyl-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethanomorphinan 
• 152518-97-3 (5R,6R,7S,9R,13S,14S)-7-Acetyl-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethanomorphinan 
• 1187639-24-2 N-nororipavine hydrochloride 
• 84712-92-5 (2S)-2-[(5R,6R,7R,14S)-N-cyclopropanoyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylbutan-2-ol 
• 5083-80-7 N-(cyclopropylmethyl)northebaine 

Downstream Products

• 1750-45-4 6-hydroxychlorzoxazone 
• 5719-85-7 4-hydroxytolbutamide 
• 91423-89-1 C₂₈H₃₇NO₃ 
• 97203-04-8 21-cyclopropyl-7α-<2-(3,3-dimethyl-1-butenyl)>-6,14-endo-ethanotetrahydrooripavine 

Related news

Effects of sedation with acepromazine maleate and buprenorphine hydrochloride (cas 136232-95-6) on femoral artery blood flow in healthy dogs09/04/2019

The purpose of this study was to qualify and quantify the femoral artery blood flow by duplex Doppler ultrasonography (DDU) in healthy dogs, before and after the administration of a combination of acepromazine maleate and buprenorphine hydrochloride (ACP–BPN). Seven healthy adult mongrel dogs a...detailed

buprenorphine hydrochloride (cas 136232-95-6) induces apoptosis in NG108-15 nerve cells09/02/2019

A morphine alkaloid derivative, buprenorphine hydrochloride, induces apoptosis in NG108-15 cells. Apoptosis was detected mainly by apoptosis-specific DNA fragmentation and morphological changes. This apoptosis was dose-dependent and the time-course experiment indicated that DNA fragmentation occ...detailed

Fabrication of an ultrasensitive impedimetric buprenorphine hydrochloride (cas 136232-95-6) biosensor from computational and experimental angles08/31/2019

For the first time, an ultrasensitive impedimetric buprenorphine hydrochloride (BN) biosensor based on immobilization of bovine serum albumin (BSA) onto multi-walled carbon nanotubes (MWCNTs)/glassy carbon electrode (BSA/MWCNTs/GCE) has been developed using initial characterization by computatio...detailed

Relevant articles and documents

Preparation of 6,14-Ethenomorphinan Derivatives

Dihydronorthevinone (2b) was prepared from dihydrothevinone (2a) with diethyl azodicarboxylate (DEAD) and transformed into a number of new N-substituted dihydronorthevinone derivatives (2c-2g).Grignard reactions of the new compounds with methylmagnesium iodide and tert-butyl-magnesium chloride were studied.O-Demethylation of 3a-3j resulted in the corresponding N-substituted buprenorphine and diprenorphine analogs 4a-4j. - Keywords: Buprenorphine; Diprenorphine; Dihydronorthevinone; N-Substituted Dihydronorthevinone; Grignard-reactions; Morphine alkaloids; O-Demethylation with DIBAL.

DEUTERATED COMPOUND AND MEDICAL USE THEREOF

The present invention relates to a compound represented by formula I and a non-toxic pharmaceutically acceptable salt thereof. In formula (I), R1 is H, CH3 or deuterated methyl (CD3); R2 is CH3 or CH2CH3; R3, R4 and R5 are each independently H or deuterium (D); when R1 is H or CH3, at least one of R3, R4 and R5 is D.

PROCESS FOR THE PREPARATION OF OPIOID COMPOUNDS

The present invention is directed to a process for the preparation of opioid compounds such as buprenorphine, naltrexone, naloxone, nalbuphone, nalbuphine, and the like.