THE MANNICH REACTION OF CARBONYL COMPOUNDS VIA SILYL ENOL ETHERS BY A COMBINATION OF CHLOROIODOMETHANE AND N,N,N',N'-TETRAMETHYLDIAMINOMETHANE

DOI: 10.1246/cl.1980.1213

Source and publish data:

Chemistry Letters p. 1213 - 1214 (1980)

Update date:2022-08-28

Topics:

Authors:

Miyano, Sotaro

Hokari, Hiroshi

Mori, Akira

Hashimoto, Harukichi

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Article abstract of DOI:10.1246/cl.1980.1213

The Mannich dimethylaminomethylation of carbonyl compounds is conveniently carried out via trimethylsilyl enol ethers by a combination of chloroiodomethane and N,N,N',N'-tetramethyldiaminomethane in DMSO or DMF as the solvent at ambient temperature.

Full text of DOI:10.1246/cl.1980.1213

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