7
254
C.-Y. Shi et al. / Bioorg. Med. Chem. Lett. 20 (2010) 7250–7254
in vitro show that the two complexes possess good cytotoxic activ-
ity against four different cell lines, especially more effective against
Hela cell lines. The presented cis-Pt(II) complex shows better
anti-tumour activity and DNA-binding characteristics than the
trans-Pd(II) complex due to the different co-ordination metal cen-
tre and geometry of the two complexes. These initial studies are
promising and may shed some light on designing new potential
anticancer agents and DNA probes in the future.
Figure 5. Electrophoretograms for interaction of pBR322 DNA with different
concentrations(6.6 M and 3.3 M) of complex 1 (lanes 1 and 2) and complex 2
lanes 3 and 4), respectively. Lane 0 applies to untreated DNA.
Acknowledgements
l
l
(
This work is supported by the National Natural Science Founda-
tion of China(no. 20671064, 20971090), Foundation of Educational
Department of Liaoning Province (no. 20060679) and the Natural
Science Foundation of Liaoning Province (no. 20052014).
Table 2
Cytotoxicity of the complexes against selected human tumour cells after 72 h of
incubation (data are expressed as mean ± SD (n = 4))
Complex
In vitro activity (IC50 ± SD, lM)
Supplementary data
Hela
Hep-G2
KB
AGZY-83a
CCDC 776692 (complex 1) and 739075 (complex 2) contain the
supplementary crystallographic data for this Letter. These data can
tal methods and procedures are available. Supplementary data
Complex 1
Complex 2
Cisplatin
1.34 ± 0.26
2.36 ± 0.32
0.96 ± 0.12
4.12 ± 0.72
4.76 ± 0.96
3.64 ± 0.72
2.68 ± 0.61
3.97 ± 0.74
1.64 ± 0.73
2.54 ± 0.49
3.27 ± 0.64
2.03 ± 0.53
40
30
20
1 0
0
Complex 1 Complex 2 Cis-DDP
3
1
29
References and notes
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4
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2
2