Stereoconvergent Synthesis of Enantiopure (-)-trans-Lauthisan. Building Kit for Medium Ring Oxacycle Construction and Contrathermodynamic Epimerization at Allylic Carbon C(8) via "Invisible", E-Configurated Medium Ring Olefin

Article abstract of DOI:10.1016/0040-4020(94)00960-3

Starting once more from simple, acyclic functionalized α,α'-chiral, disecondary ethers we have prepared enantiomerically pure (-)-trans-lauthisan (which is thermodynamically less stable than its cis epimer).During a Pd(0) catalyzed cyclization a strained