Microbial transformation of taxoids: Selective deacetylation and hydroxylation of 2α,5α,10β,14β-tetra-acetoxy-4(20),11-taxadiene by the fungus Cunninghamella echinulata

Article abstract of DOI:10.1016/0040-4020(96)00426-7

The fungal genus Cunninghamella, in particular, Cunninghamella echinulata AS 3·1990 selectively transformed 2α,5α,10β,14β-tetra-acetoxy-4(20),11-taxadiene (1) to give 6α,10β-dihydroxy-2α,5α-14β-triacetoxy-4(20),11-taxadiene (2) in moderate yield (33%), along with 6β,10β-dihydroxy-2α,5α,14β-triacetoxy-4(20),11-taxadiene (3), 10β-hydroxy-2α,5α,14β-triacetoxy-taxadiene (4), 10β-hydroxy-4β,20-epoxy-2α,5α,14β-triacetoxy-tax-11-ene (5) as minor products.