Preparation of fluorinated RNA nucleotide analogs potentially stable to enzymatic hydrolysis in RNA and DNA polymerase assays Dedicated to Dr. Teruo Umemoto on the occasion of receiving the ACS Award for Creative Work in Fluorine Chemistry.

DOI: 10.1016/j.jfluchem.2014.07.019

Source and publish data:

Journal of Fluorine Chemistry p. 226 - 230 (2014)

Update date:2022-08-30

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Authors:

Shakhmin, Anton

Jones, John-Paul

Bychinskaya, Inessa

Zibinsky, Mikhail

Oertell, Keriann

Goodman, Myron F.

Prakash, G.K. Surya

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Article abstract of DOI:10.1016/j.jfluchem.2014.07.019

Analogs of ribonucleotides (RNA) stable to enzymatic hydrolysis were prepared and characterized. Computational investigations revealed that this class of compounds with a modified triphosphate exhibits the correct polarity and minimal steric effects compa

Full text of DOI:10.1016/j.jfluchem.2014.07.019

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