D
M. M. Mane, D. M. Pore
Letter
Synlett
Table 3 Synthesis of Salicylaldehyde Azinesa
with 2-cyanoacetohydrazide (1:2) under identical reaction
conditions, thereby providing an alternative route for the
synthesis of these products.
HO
N
CHO
O
K3PO4
N
R
R
2
R
NC
NH2
+
N
EtOH
Δ
Acknowledgements
OH
OH
H
1
3
10
D.M.P. and M.M.M. are grateful to UGC, New Delhi, for financial assis-
tance [F. No. 42-394/2013 (SR)] and a teacher fellowship under FDP [F.
No. 36-50/11WRO 30/12/2012], respectively.
Entry Product
Time (h) Yield (%) mp (°C)
Supporting Information
HO
Experimental details and detail spectral data (IR, 1H and 13C NMR, and
mass spectra) of unknown synthesized compounds are provided in a
supplementary file. Supporting information for this article is avail-
N
N
204 (Lit.14
205–206)
1
10a
1.0
80
OH
S
u
p
p
o
nrtIo
g
f
rmoaitn
S
u
p
p
ortiInfogrmoaitn
Br
References
HO
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N
N
305 (Lit.10
305)
2
10b
1.0
75
OH
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Br
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OMe
HO
N
3
4
5
10c
10d
10e
1.0
85
84
75
194
N
OH
MeO
Cl
HO
N
N
285 (Lit.15
288)
0.5
OH
Cl
Cl
Cl
HO
N
N
280 (Lit.16
284)
0.60
OH
Cl
Cl
a Reaction conditions: salicylaldehyde (1.0 mmol), 2-cyanoacetohydrazide
(2.0 mmol), K3PO4 (20 mol%), EtOH (2 mL), reflux.
© Georg Thieme Verlag Stuttgart · New York — Synlett 2016, 27, A–E