First synthesis of a digitalis saponin. Demonstration of the scope and limitations of a convergent scheme for branched oligosaccharide synthesis by the logic of glycal assembly

Article abstract of DOI:10.1021/ja00126a010

The synthesis of complex glycosides, with branching at C₂, is demonstrated. The key element involves the use of a 1,2-oxirane donor. Upon glycosylation, a C₂ hydroxyl is exposed to serve as the acceptor in the next glycosylation. Bra