Chemistry of Heterocyclic Compounds p. 547 - 550 (1994)
Update date:2022-08-17
Topics:
Gitis, K. M.
Neumoeva, G. E.
Isagulyants, G. V.
The reaction of imidazoles with alcohols at 300-400 deg C was studied in the presence of heterogeneous γ-Al2O3 catalysts and Y zeolites.The major reaction was found to be N-alkylation.This reaction is accompanied by C-alkylation on γ-Al2O3, while the selectivity relative to N-alkylation is close to 100percent on zeolite catalysts.The greatest activity with 100percent selectivity was found for H zeolite.The alkylation of methanol and ethanol by 2-methylimidazole at 310-320 deg C gave 1,2-dimethylimidazole in ca. 100percent yield and 1-ethyl-2-methylimidazole in 90percent yield respectively.The reaction of methanol and imidazole gave 1-methylimidazole in 99percentyield.This catalyst displays high stability and capacity for oxidative regeneration.
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