1,2,4,5-Tetramethyl-1H-imidazole

Base Information

• Chemical Name: 1,2,4,5-Tetramethyl-1H-imidazole
• CAS No.: 1739-83-9
• Molecular Formula: C7H12 N2
• Molecular Weight: 124.186
• Hs Code.: 2933290090
• European Community (EC) Number: 217-100-7
• UNII: CUL2LRH8MG
• DSSTox Substance ID: DTXSID30169679
• Nikkaji Number: J151.115G
• Wikidata: Q83039389
• Mol file: 1739-83-9.mol

Synonyms:1,2,4,5-Tetramethylimidazole;1739-83-9;1,2,4,5-Tetramethyl-1H-imidazole;tetramethyl-1H-imidazole;1H-Imidazole, 1,2,4,5-tetramethyl-;EINECS 217-100-7;CUL2LRH8MG;SCHEMBL76902;DTXSID30169679;BAA73983;Imidazole, 1,2,4,5-tetramethyl-;MFCD00059162;1,2,4,5-Tetramethyl-1H-imidazole #;AS-47959;CS-0153599;FT-0769167;T0971;F17118;EN300-7139642;A881724

Chemical Property of 1,2,4,5-Tetramethyl-1H-imidazole

Chemical Property:

• Vapor Pressure: 20Pa at 20℃
• Boiling Point: 245.3°Cat760mmHg
• Flash Point: 102.1°C
• PSA: 17.82000
• Density: 0.96g/cm³
• LogP: 1.34530
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 124.100048391
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

99.9% ^*data from raw suppliers

1,2,4,5-Tetramethylimidazole ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N(C(=N1)C)C)C

Technology Process of 1,2,4,5-Tetramethyl-1H-imidazole

There total 7 articles about 1,2,4,5-Tetramethyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

acetaldehyde (75-07-0,9002-91-9) + dimethylglyoxal (431-03-8) + methylamine (74-89-5) → 1,2,4,5-tetramethylimidazole (1739-83-9)

Guidance literature:

With ammonium carbonate; In methanol; water; at 0 - 20 ℃; for 16h;

DOI:10.1080/00397911.2017.1330416

Reference yield:

2,4,5-trimethylimidazole hydrochloride (70807-89-5) → 1,2,4,5-tetramethylimidazole (1739-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaOC₂H₅ / ethanol / 4 h / Heating

2: 1) Na/NH₃ / 1) -78 deg C to reflux, 2) 8 h

With ammonia; sodium ethanolate; sodium; In ethanol;

Reference yield:

dimethylglyoxal (431-03-8) + methylamine (74-89-5) → 1,2,4,5-tetramethylimidazole (1739-83-9)

Guidance literature:

With ethanol; anschl. mit 2,4,6-Trimethyl-hexahydro-<1,3,5>triazin-trihydrat;

upstream raw materials:

ethanol

2,4,6-Trimethyl-[1,3,5]triazinane; hydrate

dimethylglyoxal

methylamine

Downstream raw materials:

1-[2-(4-Methanesulfonylamino-phenyl)-2-oxo-ethyl]-2,3,4,5-tetramethyl-3H-imidazol-1-ium; chloride

C₂₆H₂₈N₂P⁽¹⁺⁾*Cl^(1-)