Nucleophilic substitution on α-mesyloxy-O-alkyloximes - II. Enantiospecific synthesis of 2-(imidazol-1-yl)-1-cyclohexyl-3-phenylpropan-1-one O-alkyloximes

Article abstract of DOI:10.1016/S0957-4166(96)00506-X

An enantiospecific synthesis of (S)- and (R)-(E)-5-[1-cyclohexyl-3-phenyl-2-(imidazol-1-yl)propylidene]aminooxypentanoic acids 2 using homochiral phenylalanines as starting material is described. Protected α-hydroxy-N,O-dimethylamides 4, obtained from α-h