6214-35-3

Basic information

• Product Name: (Z)-(3)-IODOACRYLIC ACID
• Synonyms: (Z)-(3)-IODOACRYLIC ACID;CIS-3-IODOACRYLIC ACID;cis-3-Iodoacrylic acid,98%;(2Z)-3-Iodo-2-propenoic acid;2-Propenoic acid, 3-iodo-, (2Z)-;(Z)-3-iodoprop-2-enoic acid
• CAS NO: 6214-35-3
• Molecular Formula: C₃H₃IO₂
• Molecular Weight: 197.96
• Mol File: 6214-35-3.mol

Chemical Properties

• Melting Point: 65 °C
• Boiling Point: 248.3 °C at 760 mmHg
• Flash Point: 104 °C
• Appearance: White to yellow crystalline powder
• Density: 2.325 g/cm³
• Vapor Pressure: 0.00783mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (Z)-(3)-IODOACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(3)-IODOACRYLIC ACID(6214-35-3)
• EPA Substance Registry System: (Z)-(3)-IODOACRYLIC ACID(6214-35-3)

Safety Data

• Hazardous Substances Data: 6214-35-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C3H3IO2/c4-2-1-3(5)6/h1-2H,(H,5,6)/b2-1-

Upstream product

• 2956-91-4 1,1,3,3-tetraiodo-propan-2-one 
• 471-25-0 Propiolic acid 
• 74-88-4 methyl iodide 
• 6372-02-7 (E)-3-iodoacrylic acid 

Downstream Products

• 6214-23-9 methyl (2Z)-3-iodoprop-2-enoate 
• 6213-88-3 (E)-methyl 3-iodoacrylate 
• 35304-86-0 (Z)-5-phenyl-2,4-pentadien-4-olide 
• 31930-36-6 ethyl (Z)-3-iodopropenoate 
• 132971-61-0 xerulin 
• 4394-76-7 6-methyl-2H-pyran-2-one 
• 1577-96-4 (Z)-oct-2-enoic acid 
• 108-28-1 protoanemonin 

Relevant articles and documents

Diastereoselective scalable synthesis of 2,6-trans-Piperidines using an aza-Michael reaction

Highly efficient substrate and reagent controlled stereoselective synthesis of 2,6-trans-piperidine derivative (1) using an aza-Michael reaction is reported. This method was utilized to synthesize a variety of trans-piperidines on hundred-gram scales.

SIMPLE, STEREOSPECIFIC PREPARATION OF Z-3-IODOACRYLIC ACID FROM PROPIOLIC ACID AND METHYLMAGNESIUM IODIDE

Addition of propiolic acid to 2.2 equiv of methylmagnesium iodide in THF followed by workup with acetic acid produces only the Z-isomer of 3-iodoacrylic acid, 2, in high yield.

Revisiting the hydroiodination of propiolic acid

Z-3-iodoacrylic acid Z-1, that formed by reacting propiolic acid 2 with 57% aqueous III at 80-85 °C, was efficiently converted into the isomeric acid E-1 by treatment in the same conditions.

Selective Ni-catalyzed cross-electrophile coupling of alkynes, fluoroalkyl halides, and vinyl halides

We report a Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes. This mild and operationally simple protocol is distinguished by its broad substra

PYRROLO[2,3-D]PYRIMIDIN-2-ONE ANTIMICROBIAL COMPOUNDS

The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. In some embodiments, the present disclosure provides pyrrolo[2,3-d]pyrimidin-2-ones useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

AMINOMETHYLAMIDINE AND METHYLAMIDINE ANTIMICROBIAL COMPOUNDS

The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. In some embodiments, the present disclosure provides pyrrolo[2,3-d]pyrimidin-2-ones useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

Studies toward the Total Synthesis of the Marine Macrolide Salarin C

A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. The macrolactone core of 3 was assembled by Suzuki coupling between alkyl iodide 9 and

ANTIMICROBIALS AND METHODS OF MAKING AND USING SAME

The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans a

ANTIMICROBIALS AND METHODS OF MAKING AND USING SAME

The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I) or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.

Pd/C-Cu mediated direct and one-pot synthesis of γ-ylidene butenolides

10% Pd/C in combination with CuI, PPh3, and Et3N has been identified as an effective catalyst system for the coupling of (Z)-3-iodoacrylic acid with terminal alkynes in 1,4-dioxane leading to the one-pot synthesis of γ-ylidene butenolides. The methodology showed remarkable regio- and stereoselectivity as only the five-membered lactone ring products were formed with an exocyclic double bond possessing Z-geometry.