Bioorganic and Medicinal Chemistry p. 5709 - 5717 (2017)
Update date:2022-08-17
Topics:
Song, Gaopeng
Zhu, Xiang
Li, Junhua
Hu, Dekun
Zhao, Dongsheng
Liao, Yixian
Lin, Juntong
Zhang, Lian-Hui
Cui, Zi-Ning
Improvement of subtype selectivity of an inhibitor's binding activity using the conformational restriction approach has become an effective strategy in drug discovery. In this study, we applied this approach to PDE4 inhibitors and designed a series of nov
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