197573-17-4Relevant articles and documents
Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as potential PDE4 inhibitors
Song, Gaopeng,Zhao, Dongsheng,Hu, Dekun,Li, Yasheng,Jin, Hongwei,Cui, Zining
, p. 4610 - 4614 (2015)
The design, synthesis, and biological evaluation of new phosphodiesterase type 4 (PDE4) inhibitors, which possessed 7-(cyclopentyloxy)-6-methoxy 1,2,3,4-tetrahydroisoquinoline ring, were described. Compound 8 [(7-cyclopentyloxy)-6-methoxy-3,4-dihydroisoqu
Cyclopentyl: A novel protective group for phenols
Gajera, Jitendra M.,Gharat, Laxmikant A.,Farande, Aniket V.
, p. 4309 - 4312 (2007)
We have discovered cyclopentyl as a novel group for the protection of hydroxyl functionality of phenols. The key steps involved are cyclopentylation and decyclopentylation. Copyright Taylor & Francis Group, LLC.
TETRAHYDROISOQUINOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF
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Paragraph 0077-0078, (2020/12/22)
Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis. (I)
C3-substituted tetrahydroisoquinoline derivative and preparation method and application thereof
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Paragraph 0066; 0067; 0068; 0069; 0070; 0071, (2017/08/29)
The invention discloses a C3-substituted tetrahydroisoquinoline derivative. A structure formula of the derivative is shown in formula I or formula II, wherein an R1 group is hydrogen, a naphthenic group, an alkyl group, a phenyl group or a substituted phe
