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ChemComm
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DOI: 10.1039/C7CC07652E
COMMUNICATION
Journal Name
higher than those of SBC and chitosan. The results indicated structural modification to access safe and efficient nonviral
that the DMEDA- -SBC did have greatly enhanced gene vehicles for cancer-specific gene therapy in future.
delivery efficacy in various cell lines compare to the SBC. We This work was supported by the National Basic Research
further evaluated the gene delivery efficacy of DMEDA- -SBC Program of China (2015CB931801), National Natural Science
g
g
in the presence of 10% fetal bovine serum (FBS) in Fig. 4d. In Foundation of China (21504054, 51473093), and Postdoctoral
COS-7 cells, the presence of serum led to a significant decrease Science Foundation of China (2015M580321).
in transfection efficiency of DMEDA-
g-SBC, and the gene
Notes and references
expression of DMEDA- -SBC/pDNA polyplexes was much
g
lower than those of PEI and lipofectamine 2000. However,
almost no measurable decline in transfection efficacy of
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2
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Luciferase expression of SBC or DMEDA-g-SBC/pDNA
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