A highly efficient asymmetric synthesis of methoxyhomophenylalanine using Michael addition of phenethylamine

Article abstract of DOI:10.1016/S0040-4039(98)02023-1

A practical method for (S)-p-methoxyhomophenylalanine (S)-1 by using diastereoselective Michael addition as a key step was reported. Thus, the Michael addition of (S)-1-phenethylamine (S)-3 to p-methoxy-trans- benzoylacrylic acid 2 was performed in a high