BN 80927: A novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

DOI: 10.1016/S0960-894X(99)00428-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2599 - 2602 (1999)

Update date:2022-08-29

Topics:

Authors:

Lavergne, Olivier

Harnett, Jeremiah

Rolland, Alain

Lanco, Christophe

Lesueur-Ginot, Laurence

Demarquay, Daniele

Huchet, Marion

Coulomb, Helene

Bigg, Dennis C. H.

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Article abstract of DOI:10.1016/S0960-894X(99)00428-X

BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.

Full text of DOI:10.1016/S0960-894X(99)00428-X

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