BIOSYNTHESIS OF PIPERLONGUMINE

Article abstract of DOI:10.1016/S0031-9422(00)80674-3

The incorporation of L-lysine and L-phenylalanine into piperlongumine has been demonstrated in Piper longum.The subsequent stepwise degradation to methyl-(3,4,5-trimethoxyphenyl)-propanoate and δ-aminovaleric acid revealed that the C6-C3 moiety of the alkamide arises from phenylalanine; the heterocyclic ring is biosynthesized from lysine.It has also been shown that DL-<2-14C>tyrosine and <2-14C>sodium acetate are poor precursors for piperlongumine. Key Word Index - Piper longum; Piperaceae; alkamides; piperlongumine; biosynthesis.