Journal of Organic Chemistry p. 13733 - 13743 (2019)
Update date:2022-08-11
Topics:
Hu, Zhifei
Silipo, Alba
Li, Wei
Molinaro, Antonio
Yu, Biao
Forsythenethoside A (1) is a structurally unique macrocyclic phenylethanoid glycoside, which was isolated from Forsynthia suspensa and displayed considerable neuroprotective activities. Here, we report its first chemical synthesis via a longest linear sequence of 14 steps in 5% overall yield wherein intramolecular oxidative coupling was successfully employed to realize the pivotal macrocyclization. NMR analysis revealed the existence of an unexpected conformational interconversion of the congested macrocycles.
View MoreHangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
website:http://www.hybio.com.cn
Contact:+86 755 26588093
Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD
Contact:+86-531-55696072
Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
Dalian Synco Chemical Co., Ltd.
Contact:+86-411-83635150
Address:Rm 1004, 24, Tangshan Street, Dalian
Hangzhou Showland Technology Co., Ltd.
Contact:86-571-88920516
Address:ROOM2118,NO.553,WENSAN ROAD,HANGZHOU,CHINA
Doi:10.1002/ejoc.202100332
(2021)Doi:10.1016/S0040-4039(01)85027-9
(1972)Doi:10.1016/j.bcp.2004.02.012
(2004)Doi:10.1016/j.bmcl.2006.06.026
(2006)Doi:10.1002/chir.22209
(2013)Doi:10.1021/ol801382f
(2008)