Chemistry - A European Journal
10.1002/chem.201901080
COMMUNICATION
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2
a(PF
6
)
780 21
280 17
390 6.3
1390 24
240 1.2
950 4.5
2b(PF
6
)
3540
1170 59
160
[
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2c(PF
6
)
170 9.2
200 2.7
11100
75 1.4
96 6.6
320 22
62 1.5
690 18
110 7.1
[4]
2d(PF
6
)
cis-[Ru(dppm)
2
Cl
Cl
2
]
]
4700
470
5150 54
18000
2110
840
cis-[Os(dppm)
2
2
28000
330
16900
1560
24600
890
68000
9380
3
[5]
cis-[Pt(NH
)
3 2
Cl
2
]
14700
60
15100
350
16600
2460
30200
4220
3
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2 2
Cl ]. The coupling of alkyne
α
Pdppm bond
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[
2
2
a
energetically feasible mechanism for the formation of these
bicyclic metallafurans. Most importantly, these air and moisture
stable phosphonium-containing metallafurans exhibit stronger
cytotoxicity against several common human cancer cell lines
compared with their corresponding metal precursors and the
classic anticancer agent cisplatin, and are able to induce
mitochondrial dysfunction in cells, which suggests that the
metallafurans may potentially serve as alternative anticancer
agents.
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Acknowledgements
The work described in this paper was supported by the
Research Grants Council of Hong Kong SAR (CityU 11228316,
CityU 11207117 and T42-103/16-N).
1
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1
Keywords: Alkyne Activation • Metallacycles • Osmium •
Tse, H.-S. Lo, S.-C. Chan, M.-K. Tse, S.-M. Yiu, C.-Y. Wong, Dalton
Trans. 2018, 47, 12838-12842.
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