O-alkylation of bioactive phthalimide derivatives under microwave irradiation in dry media

Article abstract of DOI:10.1080/00397910008086969

In this paper we describe the synthesis of a new series of substituted 2-(4-alkoxy or 4-acyloxyphenethyl)-phthalimide derivatives (4-11), in good yields (58-87%), exploring the remarkable fast O-alkylation or O-acylation of 2-(4-hydroxyphenethyl)-phthalimide (3) in dry media under microwave irradiation.

Full text of DOI:10.1080/00397910008086969

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Synthetic Communications: An
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O-Alkylation of Bioactive
Phthalimide Derivatives Under
Microwave Irradiation in Dry
Media
Lidia M. Lima a , Eliezer J. Barreiro a & Carlos A. M.
Fraga b
a Laboratorio de Avaliaçäo e Síntese de
Subst[acaron]ncias Bioativas (LASSBio, http://
acd.ufrj.br/~pharma/lassbio), Faculdade de
Farmácia, Universidade Federal do Rio de Janeiro,
PO Box 68006,21944-970, Rio de Janeiro, RJ, Brazil
b Institute de Química, Universidade Federal do Rio
de Janeiro, Rio de Janeiro, RJ, Brazil
Version of record first published: 04 Dec 2007.
To cite this article: Lidia M. Lima , Eliezer J. Barreiro & Carlos A. M. Fraga (2000):
O-Alkylation of Bioactive Phthalimide Derivatives Under Microwave Irradiation in Dry
Media, Synthetic Communications: An International Journal for Rapid Communication
of Synthetic Organic Chemistry, 30:18, 3291-3306
To link to this article: http://dx.doi.org/10.1080/00397910008086969
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