24685-08-3

Basic information

• Product Name: 1-(MORPHOLINO(PHENYL)METHYL)NAPHTHALEN-2-OL
• Synonyms: 2-Naphthol,1-(a-morpholinobenzyl)- (8CI); NSC79464
• CAS NO: 24685-08-3
• Molecular Formula: C₂₁H₂₁NO₂
• Molecular Weight: 319.3969
• Mol File: 24685-08-3.mol

Chemical Properties

• Boiling Point: 481.3°Cat760mmHg
• Flash Point: 244.9°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 6.87E-10mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: 1-(MORPHOLINO(PHENYL)METHYL)NAPHTHALEN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(MORPHOLINO(PHENYL)METHYL)NAPHTHALEN-2-OL(24685-08-3)
• EPA Substance Registry System: 1-(MORPHOLINO(PHENYL)METHYL)NAPHTHALEN-2-OL(24685-08-3)

Safety Data

• Hazardous Substances Data: 24685-08-3(Hazardous Substances Data)

Usage

Chemical structure

Naphthalene derivative
The compound is derived from naphthalene, a type of aromatic hydrocarbon consisting of two fused benzene rings.

Structural features

Contains a morpholine ring and a phenyl group
The compound has a morpholine ring, which is a six-membered heterocyclic amine, and a phenyl group, which is a six-carbon aromatic ring with a single bond to a carbon atom.

Attachment

Morpholine ring and phenyl group are attached to a naphthalen-2-ol moiety

Potential applications

Pharmaceutical and medicinal chemistry
Due to its structural features and potential biological activities, the compound may be useful in the development of new drugs and therapies.

Additional applications

Organic synthesis and materials science
The compound may also be utilized in the synthesis of other organic compounds and in the development of new materials with specific properties.

Research and development

Ongoing investigation into properties and potential uses
Further research is needed to fully understand the compound's properties and to explore its potential applications in various fields.

Biological activities

Not explicitly mentioned in the material
The specific biological activities of 1-(Morpholino(phenyl)methyl)naphthalen-2-ol are not detailed in the provided material, but its potential applications in pharmaceutical and medicinal chemistry suggest that it may have relevant biological activities.

InChI:InChI=1/C21H21NO2/c23-19-11-10-16-6-4-5-9-18(16)20(19)21(17-7-2-1-3-8-17)22-12-14-24-15-13-22/h1-11,21,23H,12-15H2

Upstream product

• 110-91-8 morpholine 
• 100-52-7 benzaldehyde 
• 135-19-3 β-naphthol 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 98-80-6 phenylboronic acid 
• 53189-89-2 N-(benzylidene)morpholinium chloride 
• 370555-58-1 N-benzylmorpholine-N-oxide 
• 120803-36-3 1-morpholino[(phenyl)methyl]benzotriazole 
• 875-83-2 sodium 2-naphtholate 
• 481-82-3 1-(α-aminobenzyl)-2-naphthol 

Downstream Products

• 35173-74-1 3,3'-bis-indolyl(phenyl)methane 
• 36441-31-3 1-benzyl-2-naphthol 
• 24685-02-7 4-[(2-methoxy-naphthalen-1-yl)-phenyl-methyl]-morpholine 

Relevant articles and documents

β-naphthol in glycerol: A versatile pair for efficient and convenient synthesis of aminonaphthols, naphtho-1,3-oxazines, and benzoxanthenes

Three-component Betti reaction was carried out in the environmentally benign, inexpensive, non-toxic solvent glycerol. Even in the absence of a catalyst, the reaction went completion with an unprecedented high rate and the expected Betti bases were obtained in up to 91% yield. The reaction works well for representative cyclic, acyclic, aliphatic, and aromatic amines and aldehydes. A benzoxanthene was also prepared in 93% yield following the same methodology with 20 mol% methanesulfonic acid catalyst. Georg Thieme Verlag Stuttgart New York.

Synthesis, growth, physicochemical properties and DFT calculations of 2-naphthol substituted Mannich base 1-(morpholino(phenyl) methyl) naphthalen-2-ol: A non linear optical single crystal

2-Naphthol substituted Mannich base 1-morpholino(phenyl)methyl)naphthalen-2-ol (MPMN), a potential NLO active organic single crystal was developed using acetonitrile as a solvent by slow evaporation method. The experimental and theoretical analysis made t

Facile synthesis of aminoalkyl naphthols and single crystal X-ray, computational studies on 1-[morpholino(thiophen-2-yl)methyl]naphthalen-2-ol

An efficient, eco-friendly protocol is developed for the synthesis of 1- (α-aminoalkyl)-2-naphthol derivatives via one-pot three-component reaction of 2-naphthol, aromatic aldehydes and piperidine or morpholine in the presence of Amberlite IRA-400 Cl resi

Synthesis of 1-aminoalkyl-2-naphthols derivatives using an engineered copper-based nanomagnetic catalyst (Fe3O4@CQD@Si (OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu)

In the present study, a molecular level engineered-based method was used to synthesis a copper-based nanomagnetic catalyst (Fe3O4@CQD@Si (OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu). The as-synthesized cat

An efficient, multicomponent synthesis of aminoalkylnaphthols via Betti reaction using ZSM-5 as a recoverable and reusable catalyst

The design and application of environmentally friendly catalysts to reduce the number of toxic wastes are critical for improving the chemical synthetic protocols. A simple, mild, efficient, and eco-friendly method was developed for the synthesis of a seri

Design and identification of nano-Mg-[4-methoxy phenyl-salicylaldimine–methyl-pyranopyrzole] Cl2 and its catalytic application on the preparation of 1-(α-aminoalkyl)-2-naphthols

Nano-Mg- [4-methoxy phenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Mg-4MSMP]Cl2) as a nano-Schiff base complex was prepared and fully characterized using some various techniques including fourier transform infrared spectroscopy

Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives

A peroxide-free methodology was developed for the synthesis of benzoylated naphthol/phenol derivatives through oxidative deamination reaction performed under aerobic reaction conditions. A synergistic combination of Cu(OTf)2 and Ag2O was used to convert the aminonaphthols and aminophenols to the corresponding benzoylated derivatives. The definite role of atmospheric oxygen to assist the reaction was proved by performing the reaction in the argon atmosphere.

Synthesis of Betti base derivatives catalyzed by nano-CuO-ionic liquid and experimental and quantum chemical studies on corrosion inhibition performance of them

In this research, for the first time, aminonaphthol derivatives were introduced as efficient corrosion inhibitors. A linear polarization method was employed to investigate the corrosion inhibitory effect of the synthesized aminonaphthols at a concentratio

Microwave-assisted nanocatalysis: A CuO NPs/rGO composite as an efficient and recyclable catalyst for the Petasis-borono-Mannich reaction

A CuO NP decorated reduced graphene oxide (CuO NPs/rGO) composite was synthesized and characterized using various analytical techniques viz. XRD, TEM, SEM, UV-Vis, FT-IR, EDX, XPS and CV. The activity of the catalyst was probed for the Petasis-Borono-Mann

Multicomponent reaction in deep eutectic solvent for synthesis of substituted 1-aminoalkyl-2-naphthols

One-pot multicomponent synthesis of Betti bases (aminoalkyl naphthols) from aldehydes, β-naphthol, and secondary amines in deep eutectic solvent (DES) based on urea and choline chloride has been developed. A broad range of aminoalkyl naphthols can be obta