Synthesis of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides

Article abstract of DOI:10.1080/15257779908041508

The preparation of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides is [4-11] is described. The key steps of this synthesis are the nucleophilic displacements of a chlorine by a thioalkyl sodium salt or the direct introduction of the thioalkyl group under Mitsunobu conditions.

Full text of DOI:10.1080/15257779908041508

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Nucleosides and Nucleotides
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Synthesis of 5′-Thioalkyl, Sulfoxide and
Sulfone Pyrimidine Nucleosides
L. A. Agrofoglio a , F. Girard a , F. Fleury a & S. Léonce b
a I. C. O. A., associé au CNRS, Faculté des Sciences , 45067, Orléans,
France
b Institut de Recherche Servier , 11 rue des Moulineaux, 92150,
Suresnes, France
Published online: 04 Oct 2006.
To cite this article: L. A. Agrofoglio , F. Girard , F. Fleury & S. Léonce (1999) Synthesis of 5′-
Thioalkyl, Sulfoxide and Sulfone Pyrimidine Nucleosides, Nucleosides and Nucleotides, 18:4-5,
599-600, DOI: 10.1080/15257779908041508
To link to this article: http://dx.doi.org/10.1080/15257779908041508
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