Synthesis of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides

Article abstract of DOI:10.1080/15257779908041508

The preparation of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides is [4-11] is described. The key steps of this synthesis are the nucleophilic displacements of a chlorine by a thioalkyl sodium salt or the direct introduction of the thioalkyl group under Mitsunobu conditions.