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14636-12-5 Usage


N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin, also known as Terlipressin acetate, is a novel synthetic long-acting vasopressin preparation. It is a prodrug that is inactive by itself and acts as a reservoir, releasing the active lysine vasopressin at a steady rate after the action of aminopeptidase in the body. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is a white solid and is an analogue of vasopressin.


Used in Pharmaceutical Industry:
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is used as a vasoactive drug for the management of hypotension. It is particularly effective in treating norepinephrine-resistant septic shock and hepatorenal syndrome, as well as in the treatment of acute variceal bleeding.

Pharmacological effects

Terlipressin is a novel long-acting synthetic vasopressin reagent,its chemical name is three glycyl lysine vasopressin, it is a prodrug, itself has no activity ,in vivo? , it removes three glycyl residues in its N-terminus by aminopeptidase, and slowly "releases" the active lysine vasopressin. It is this "slow release" mechanism that makes it maintain the smooth muscle contraction up to 10 hours after a single administration, whereas the same dose of vasopressin, it can maintain its activity for 20-40 minutes. On the other hand,because of the slow digestion,? lysine vasopressin in the circulation cannot reach toxic levels, and usage of? terlipressin is safer. Pharmacological effect of terlipressin is splanchnic vascular smooth muscle contraction, and reduction of visceral blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal vein blood flow,and reducing portal pressure, on the other hand it may also reduce plasma renin concentration, thereby increasing the renal blood flow in patients with hepatorenal syndrome, to improve kidney function, and increase urine output. Terlipressin is currently the only drug which is able to increase mortality in patients with esophageal varices bleeding , it is previously mainly used in clinical for the treatment of variceal bleeding, in addition,terlipressin now has also been successfully used for liver and kidney integrated syndrome and refractory shock, it is also likely to play a useful role in the cardiopulmonary resuscitation . Compared with vasopressin, it has a lasting effect, and it does not cause dangerous complications, including promoting? fibrinolysis and severe complications in the cardiovascular systems, and the use of it is simple (available intravenous injection), it is more suitable for rescue and treatment of emergent and critical? patients.

Mechanism of Action

Terlipressin, a synthetic triglycyl-lysine derivative of vasopressin, is a inactive prodrug. It has pressor and antidiuretic effects. Following IV injection, lysine vasopressin are released following the enzymatic cleavage of 3 glycyl moieties. Duration: 4-6 hr.

Adverse Drug Reactions

Abdominal cramps, cardiac arrhythmias, headache, transient blanching, increased arterial pressure. Potentially Fatal: MI, cardiac failure.

Clinical Use

Treatment of bleeding oesophageal varices

Drug interactions

Potentially hazardous interactions with other drugs None known


Terlipressin is metabolised by tissue peptidases resulting in the slow release of lypressin. Terlipressin is almost completely metabolised in the kidneys and liver, with less than 1% of terlipressin and less than 0.1% of lypressin excreted in the urine.

Check Digit Verification of cas no

The CAS Registry Mumber 14636-12-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,3 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 14636-12:
95 % 10 = 5
So 14636-12-5 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017


1.1 GHS Product identifier

Product name Terlipressin

1.2 Other means of identification

Product number -
Other names N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14636-12-5 SDS

14636-12-5Synthetic route












With blood serum of pregnant women In water at 37℃; for 1h; Kinetics; other pH;

14636-12-5Upstream product

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