Journal of the American Chemical Society p. 3192 - 3198 (1981)
Update date:2022-08-25
Topics:
Maggiora, Linda
Chang, Charles C. T.-C.
Torrence, Paul F.
Mertes, Mathias P.
5-Nitro-2'-deoxyuridine 5'-phosphate (2) was found to be a mechanism-based affinity label for thymidylate synthetase purified from amethopterin resistant Lactobacillius casei.The inhibition proceeds in two steps via the initial formation of the noncovalent complex 3 (Ki = 5<*>10-7 M) which is converted to the covalent complex 4. The net dissociation constant for the overall sequence is 6.5<*>10-10 M, a value predicted from model studies of the bimolecular reaction of 2-mercaptoethanol with 5-nitrouridine or 2.
View More
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
He Bei Shun Er Chemical Co., LTD.
Contact:86-0311-86996932/86860168
Address:No 18,North street
website:http://www.finetechnology-ind.com
Contact:86-27-87465837
Address:wuhan
ShiJiaZhuang Dowell Chemical Co.,Ltd.
website:http://www.dowechem.com
Contact:+86-13463963265，+86-311-89805679
Address:Xiyangling village, high tech Zone, Shijiazhuang，Hebei, China
Wuhan Konberd Biotech Co., Ltd.
Contact:+86-27-87205925
Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Doi:10.1016/j.molcatb.2011.02.013
(2011)Doi:10.1007/s11746-007-1056-2
(2007)Doi:10.1021/jo01329a047
(1979)Doi:10.1080/14756366.2018.1434519
(2018)Doi:10.1021/ja01364a060
()Doi:10.1021/jo0613131
(2006)
