Journal of Molecular Liquids (2021)
Update date:2022-08-25
Topics:
Kumar, Harsh
Sharma, Pooja
The present examination focuses on understanding the micellization behavior of surface active ionic liquids 1-tetradecyl-3-methylimidazolium bromide [C14mim] [Br] and 1-pentadecyl-3-methylimidazolium bromide [C15mim] [Br] in presence of antidiabetic drug metformin hydrochloride by employing conductivity measurements and IR spectroscopy. The CMC value and value of counter ion dissociation (α) has been calculated by utilizing conductivity measurements. The dependency of CMC value evaluated from conductivity measurements in aqueous medium and presence of different weight percentage (0.03, 0.05 & 0.07) of drug metformin hydrochloride in aqueous medium and at different temperatures (298.15, 308.15 & 318.15) has been employed to calculate various thermodynamic parameters such as standard free energy of micellization (ΔGm0), standard enthalpy of micellization (ΔHm0), and standard entropy of micellization (ΔSm0). There is a significant increase in CMC value with the rise in temperature signifying delay in micellization process with increasing temperature. Further, the structural alterations prevailing in the selected system (ionic liquid-drug) has been determined by FT-IR Spectroscopy.
View MoreShijiazhuang City Xiehe Pharmaceutical Co., Ltd
Contact:+86-311-80817929
Address:Shangzhuang,Shijiazhuang,China
Quhua Zhongxing Refrigeration Technology Co.,Ltd.
Contact:+86-5708886618
Address:318 Bulding 2, No.866 Quhua Rd.,Kecheng District
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
Liao Cheng All Win Chemicals Co.,LTD
Contact:86+0635-2991582
Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China
Neworld Chemical Co., Ltd Shanghai
Contact:+86-21-62202658
Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Doi:10.1271/bbb.62.1301
(1998)Doi:10.1039/c39930000025
(1993)Doi:10.1016/0022-328X(91)86297-4
(1991)Doi:10.1039/FT9969202671
(1996)Doi:10.1039/c5tc03308j
(2016)Doi:10.1016/S0040-4039(98)00017-3
(1998)