Five new steroidal saponins from the seeds of Solanum melongena L.

Article abstract of DOI:10.1016/j.phytol.2020.10.008

Two novel cholestane-type steroidal saponins, melongoside R-S (1-2) and three novel furostanol-type steroidal saponins, melongoside T-V (3-5), together with three known steroidal saponins (6-8) were isolated from the seeds of Solanum melongna L. The struc

Full text of DOI:10.1016/j.phytol.2020.10.008

A338
JACC March 17, 2015
Volume 65, Issue 10S
Arrhythmias and Clinical EP
inCrEasEd Qt Variability indEx is assoCiatEd with Mortality in inCidEnt hEModialysis
patiEnts
Poster Contributions
Poster Hall B1
Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m.
Session Title: New Insights from the Electrocardiogram
Abstract Category: 7. Arrhythmias and Clinical EP: Other
Presentation Number: 1147-237
Authors: Larisa G. Tereshchenko, Sanjoli Sur, Lucy Meoni, Tejal Gambhir, Maggie Maly, Bernard Jaar, Stephen Sozio, Michelle Estrella,
Rulan Parekh, Oregon Health and Science University, Portland, OR, USA
background: Risk stratification in end-stage renal disease (ESRD) is needed to improve outcomes in patients on hemodialysis. Increased
QT variability index (QTVI) is a well-known risk marker. We hypothesized that QTVI is associated with mortality in incident hemodialysis
patients.
Methods: Orthogonal ECG was recorded at rest in a prospective cohort of incident hemodialysis patients. Premature atrial and ventricular
beats with one subsequent sinus beat were excluded. Beat-by-beat QT and RR intervals were measured by customized Matlab software.
Sinus rhythm 5-min ECGs were analyzed. QTVI was calculated as log-transformed ratio of normalized QT variance to normalized heart
rate variance. All-cause mortality served as a primary outcome.
results: Data from 308 participants (mean age 54.4±13.5 y; 58% male; 74% black; mean left ventricular ejection fraction (LVEF)
65.5±11.9%) were analyzed. During 2.4±1.2 years of follow-up, 56 patients (18%) died. In univariable analysis QTVI associated with
mortality: HR per 1-standard deviation (SD) 1.3; 95%CI 1.0-1.68; P=0.047. In multivariable Cox regression, after adjustment for age, sex,
race, prevalent coronary heart disease (CHD), left ventricular ejection fraction (LVEF), QTVI was associated with higher mortality: HR per
1-SD 1.33; 95%CI 1.01-1.74; P=0.040. HR per range of QTVI values was 4.4; 95%CI 1.08 - 17.78 (Figure).
Conclusion: Increased QTVI is associated with mortality in incident hemodialysis patients after adjustment for LVEF and prevalent CHD.