478518-52-4

Usage

Uses

Used in Pharmaceutical Applications:
6-DEOXY-L-[UL-13C6]GALACTOSE is used as a research tool for studying the metabolism and function of sugars in biological systems. The stable isotope labeling allows for the tracking and analysis of the compound's interactions and pathways within the body, providing valuable insights into sugar metabolism and its role in various physiological processes.
Used in Cosmetics Industry:
6-DEOXY-L-[UL-13C6]GALACTOSE is used as an active ingredient in the development of cosmetic products, particularly those targeting skin health and aging. 6-DEOXY-L-[UL-13C6]GALACTOSE may have potential benefits in improving skin elasticity, hydration, and overall appearance by modulating sugar-related processes in the skin.
Used in Analytical Chemistry:
6-DEOXY-L-[UL-13C6]GALACTOSE is employed as a reference material or internal standard in analytical chemistry, particularly in mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The stable isotope labeling provides a distinct signature that can be used to accurately measure and quantify other compounds in a sample, improving the precision and reliability of analytical results.
Used in Metabolic Research:
6-DEOXY-L-[UL-13C6]GALACTOSE is used as a tracer compound in metabolic research, allowing scientists to study the metabolic pathways and enzyme activities related to sugar metabolism. The stable isotope labeling enables the differentiation between endogenous and exogenous sugars, providing a clearer understanding of the metabolic processes involved.
Used in Drug Development:
6-DEOXY-L-[UL-13C6]GALACTOSE may be used in the development of new drugs targeting sugar-related diseases or conditions, such as diabetes or certain types of cancer. The stable isotope labeling can help researchers identify potential drug targets and optimize the design of therapeutic compounds.
Used in Food Industry:
6-DEOXY-L-[UL-13C6]GALACTOSE could potentially be used in the food industry for the development of novel sweeteners or additives with unique properties. The stable isotope labeling may provide insights into the sensory and metabolic effects of these compounds, leading to the creation of innovative products with improved taste, texture, or health benefits.

Upstream product

• 15814-59-2 (2S,3S,4S,5S,6R)-2-methoxy-6-methyltetrahydro-2H-pyran-3,4,5-triol 
• 7664-93-9 sulfuric acid 
• 106293-98-5 6-deoxy-D-mannono-1,4-lactone 
• 1051388-66-9 (1β,3β,5β,25S)-spirostan-1,3-diol 1-[α-L-rhamnopyranosyl-(1->2)-β-D-fucopyranoside] 
• 1253285-17-4 26-O-β-D-glucopyranosyl-(25R)-5α-furostan-20(22)-en-3β,26-diol-3-O-β-D-xylopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-galactopyranoside 
• 1198083-03-2 3α,11α,30-trihydroxylup-23-al-20(29)-en-28-oic acid 28-O-[α-L-rhamnopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-β-D-glucopyranosyl] ester 
• 6130-58-1 kaempferol-3-rutinoside 
• 153-18-4 rutin 
• 20031-16-7 γ lactone of d-isorhamnonic acid 

Downstream Products

• 128613-55-8 trifluoroacetylated 6-deoxymannose anti-O-benzyloxime 
• 128613-64-9 trifluoroacetylated 6-deoxymannose syn-O-benzyloxime 
• 128613-99-0 trimethylsilyl ether of 6-deoxymannose-anti-O-benzyloxime 
• 128614-00-6 trimethylsilyl ether of 6-deoxymannose-syn-O-benzyloxime 
• 2079-46-1 arabino-6-deoxy-[2]hexosulose-bis-phenylhydrazone 
• 128613-57-0 trifluoroacetylated 6-deoxyglucose anti-O-benzyloxime 
• 128613-68-3 trifluoroacetylated 6-deoxyglucose syn-O-benzyloxime 
• 128614-01-7 trimethylsilyl ether of 6-deoxygalactose-anti-O-benzyloxime 
• 42927-37-7 6-deoxy-talose-(methyl-phenyl-hydrazone) 
• 77144-62-8 O³,O⁵;O⁴,O⁶-((Ξ,Ξ)-dibenzylidene)-1-deoxy-D-altritol 
• 71202-84-1 D-fucose-(toluene-4-sulfonylhydrazone) 
• 100300-50-3 D-Fucose-benzylphenylhydrazon 
• 128613-53-6 trifluoroacetylated 6-deoxygalactose anti-O-benzyloxime 
• 128613-69-4 trifluoroacetylated 6-deoxygalactose syn-O-benzyloxime 

Relevant academic research and scientific papers

Chemical constituents of Euonymus fortunei

A new flavonol glycoside, kaempferol-3-O-β-d-(2-O-E-p-coumaroyl)-glucopyranosyl-7-O-α-l-rhamnopyranoside (1), along with eleven known compounds including five flavonol glycosides (2-6), one phenolic glycoside (7), two megastigmane glycosides (8 and 9), two triterpenoids (10 and 11) and one alditol (12), was isolated from the aerial parts of Euonymus fortunei. Their structures were determined on the basis of spectroscopic analysis and chemical evidence. Compounds 2-4, 7, 8, and 10-12 were evaluated their antimicrobial activities against Ureaplasma urealyticumin vitro, but all tested compounds have no useful activities against Ureaplasma urealyticum.

Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells

An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The structures and configurations of all compounds were elucidated by NMR, HRESIMS, UV, IR, and CD. The anti-cancer potency of twenty diarylheptanoids and four previously isolated compounds (7, 10, 12, 13) was investigated in human non-small cell lung carcinoma cell lines (sensitive and multi-drug resistant variants) as well as in normal human keratinocytes. Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-β-d-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. Compounds 4, 9, 14, and 18 displayed significant selectivity towards the cancer cells. Structure/activity analysis of twenty-four closely related diarylheptanoids revealed a high dependence of cytotoxic action on the presence of a carbonyl group at C-3. Substitution of a heptane chain on C-5 and a number of hydroxyl groups in the aromatic rings also emerged as a significant structural feature that influenced their cytotoxic potential.

Five new steroidal saponins from the seeds of Solanum melongena L.

Two novel cholestane-type steroidal saponins, melongoside R-S (1-2) and three novel furostanol-type steroidal saponins, melongoside T-V (3-5), together with three known steroidal saponins (6-8) were isolated from the seeds of Solanum melongna L. The struc

Steroidal saponins from Raphia vinifera and their cytotoxic activity

Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1–4), along with six known secondary metabolites (6–10). The structures of the isolated compounds were determined based on the analyses of NMR and

Flavonoids with hepatoprotective activity from the leaves of Cleome viscosa L.

One new flavonol glycoside named visconoside C (1), together with seven known flavonol glycosides, quercetin 3-O-β-d-glucopyranoside 7-O-α-l-rhamnopyranoside (2), quercetin 7-O-α-l-rhamnopyranoside (3), astragalin (4), kaempferol 3-O-(4-O-acetyl)-α-l-rham

Chemical constituents of the bulbs of scilla peruviana and their pancreatic lipase inhibitory activity

Scilla species are used as medicinal plants and contain lanosterol-type triterpene glyco-sides. The phytochemical investigation of the bulbs of Scilla peruviana led to the isolation of 17 com-pounds, including three new rearranged pentacyclic-lanosterol glycosides (1?3) and two new ho-moisoflavanone glycosides (12 and 13). The structures of the undescribed compounds were deter-mined by extensive spectroscopic analyses, including two-dimensional (2D) NMR. Among the triterpene glycosides, 2, 3, and 6 showed significant pancreatic lipase inhibitory activity in a concen-tration-dependent manner in vitro. The oral administration of scillascilloside D-2 (6) reduced serum triglyceride levels in a dose-dependent manner in soybean oil-loaded mice.

Antiproliferative activity of new pentacyclic triterpene and a saponin from: Gladiolus segetum Ker-Gawl corms supported by molecular docking study

A new triterpenoidal saponin identified as 3-O-[β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 4)-β-d-xylopyranosyl]-2β,3β,16α-trihydroxyolean-12-en-23,28-dioic acid-28-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 2)-α-l-arabinopyranoside 1 together with a new oleanane triterpene identified as 2β,3β,13α,22α-tetrahydroxy olean-23,28-dioic acid 2 and 6 known compounds (3-8) have been isolated from Gladiolus segetum Ker-Gawl corms. The structural elucidation of the isolated compounds was confirmed using different chemical and spectroscopic methods, including 1D and 2D NMR experiments as well as HR-ESI-MS. Moreover, the in vitro cytotoxic activity of the fractions and that of the isolated compounds 1-8 were investigated against five human cancer cell lines (PC-3, A-549, HePG-2, MCF-7 and HCT-116) using doxorubicin as a reference drug. The results showed that the saponin fraction exhibited potent in vitro cytotoxic activity against the five human cancer cell lines, whereas the maximum activity was exhibited against the PC-3 and A-549 cell lines with the IC50 values of 1.13 and 1.98 μg mL-1, respectively. In addition, compound 1 exhibited potent activity against A-549 and PC-3 with the IC50 values of 2.41 μg mL-1 and 3.45 μg mL-1, respectively. Interestingly, compound 2 showed the maximum activity against PC-3 with an IC50 of 2.01 μg mL-1. These biological results were in harmony with that of the molecular modeling study, which showed that the cytotoxic activity of compound 2 might occur through the inhibition of the HER-2 enzyme.

Cycloartane glycosides from Astragalus plumosus var. krugianus and evaluation of their antioxidant potential

The methanol extracts of Astragalus plumosus var. krugianus Chamb. & Matthews afforded sixteen cycloartane glycosides among which krugianoside A, was never reported before. All compounds were evaluated for their cytotoxic activity in human skin fibroblast WS1 cells. For compounds exhibiting no significant effect on WS1 viability, the antioxidant potential was examined. Compounds 1 and 8 prevented elevation of ROS induced by t-BOOH, suggesting the potential activity of these compounds to protect fibroblasts from oxidative stress.

Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition

Three triterpene glycosides were isolated from the roots of Weigela florida “rumba” (Bunge) A. DC.: two previously undescribed 3-O-β-D-xylopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-xylopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-

A new steroidal glycoside from the fruits of Solanum myriacanthum

A new cholestane-type steroidal glycoside, solamyriaside A (1), was isolated from the fruits of Solanum myriacanthum Dunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A (2) and aculeatiside A (3), and three known steroidal alkaloid glycosides, namely, solamargine (4), khasianine (5) and solasonine (6), which were isolated for the first time from this plant. Based on spectroscopic data as well as chemical evidence, 1 was determined to be 3-O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyl-22R,25R-cholest-5-ene-3β,16α,22,26-tetraol 26-O-β-D-glucopyranoside. The cytotoxic activity of 1–6 against HL-60 human promyelocytic leukaemia cells was examined. Compounds 4–6 showed cytotoxic activity. Among them, 4 exhibited the strongest activity with an IC50 value of 4.64 ± 0.17 μM, similar to the activity of cisplatin, a positive control.