Coumarins from the Fruits of Micromelum minutum
531
(KKU-100), KB, NCI-H187 and MCF-7. Among these,
(1984).
7
and
8
showed strong cytotoxicity against cholangio- Imai, F., Kinoshita, T., Itai, A., and Sankawa, U., Acid-
catalyzed rearrangement of an epoxy coumarin phebalosin
cacinoma (KKU-100) cell line (respective IC50 values
the revised structure of murrlongin. Chem. Pharm. Bull.
,
of 1.7 and 2.9
weak antimycobacterial activity against Mycobacterium
tuberculosis (MIC 50 g/mL for both).
µg/mL). In addition, 2 and 5 showed
34, 3978-3981 (1986).
Ito, C., Furukawa, H., Ishii, H., Ishikawa, T., and Haginiwa,
J., The chemical composition of Murraya paniculata. The
structure of five new coumarins and one new alkaloid and
the stereochemistry of murrangatin and related coumarins.
J. Chem. Soc. Perkin Trans. 1, 2047-2055 (1990).
µ
ACKNOWLEDGEMENTS
R. Lekphrom thanks the Thailand Research Fund
via the Royal Golden Jubilee Ph.D. program (PHD/
240/2549) and the Center for Innovation in Chemistry
Postgraduate Education and Research in Chemistry
PERCH-CIC), Ministry of Education, Thailand, for a
Kamperdick, C., Phuong, N. M., Sung, V. T., Schmidt, J.,
and Adam, G., Coumarins and dihydrocinnamic acid
0
derivatives from Micromelum falcatum. Phytochemistry,
52, 1671-1676 (1999).
(
Lamberton, J. A., Price, J. R., and Redcliffe, A. H., Micromelin,
a new coumarin from Micromelum minutum. Aust. J.
Chem., 20, 973-979 (1967).
scholarship. We are grateful for financial support from
Khon Kaen University via the Natural Products
Research Unit. We are also indebted to the Bioassay Lee, K. H. and Soine, T. O., Coumarins. X. Spectral studies
Research Facility of the National Center for Genetic
Engineering and Biotechnology for the bioactivity tests.
on some linear furanocoumarins. J. Pharm. Sci., 58, 681-
683 (1969).
We acknowledge Ms Sasitorn Siriseree, Department of Pongboonrod, S., Maitet Muang Thai. Kasembunakij Press,
Botany, Faculty of Science, Kasetsart University for
identification of the plant material.
Bangkok, pp. 624, (1958).
Rahmani, M., Susidarti, R. A., Ismail, H. B. M., Sukari, M.
A., Yun Hin, T.-Y., Ee Cheng Lian, G., Ali, A. M., Kulip, J.,
and Waterman, P. G., Coumarins from Malaysian
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