Organic Process Research & Development
Article
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41) The oxidation of benzaldehyde is monophasic, and the flow
ratio refers to the different flow rates of bleach and the starting
material.
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Synthesis of tert-Butyl Peroxypivalate Using a Single-Channel
Microreactor Equipped with Orifices as Emulsification Units.
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which would cause safety and selectivity concerns. The bleach is more
stable at pH >9, and therefore, we kept the pH slightly above 9 (9.3−
9
.5) for all runs. For future work, we plan to use a safer oxidizing
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33) Leduc, A. B.; Jamison, T. F. Continuous Flow Oxidation of
(
(
Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabuty-
lammonium Bromide. Org. Process Res. Dev. 2012, 16, 1082−1089.
(
34) Our goal was to achieve full conversion in one pass in the
Corning reactor, but we were limited by the number of plates.
Therefore, we had to use a higher concentration of the PTC and
NaOCl to speed up the reaction. The amounts of PTC and NaOCl
can be reduced when more plates are used. The concentration of
NaOCl we are using now is the highest we can find in the market.
Although the aqueous phase can be continuously separated and
reused, the concentration is lower after the recycle, therefore slowing
the reaction.
F
dx.doi.org/10.1021/op500158h | Org. Process Res. Dev. XXXX, XXX, XXX−XXX