Chemistry - A European Journal
10.1002/chem.201801757
COMMUNICATION
at a defined moment. Nevertheless, we stress that further
extensive studies and optimizations will be needed for application
of this proof of concept in cellulo or in vivo. Fortunately, recent
reports show that the toxicity of Cu(I) can be reduced by the use
of proper ligands, suggesting that, to certain extent, the CuAAC
reactions may be biocompatible and can be performed in living
cells.[ Studies along these lines are under way in our labs.
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This work was supported by the Czech Academy of Sciences
(
RVO: 61388963 and the Praemium Academiae award to M.H.)
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