Chemical and Pharmaceutical Bulletin p. 278 - 280 (2000)
Update date:2022-08-11
Topics:
Ikegami, Fumio
Yamamoto, Akemi
Sekine, Toshikazu
Ishikawa, Tsutomu
Kusamae-Eguchi, Kuniko
Kusama, Tadashi
Watanabe, Kazuko
A novel isoxazole derivative, O-(5-isoxazolyl)-L-serine (OIS, 1), was synthesized by a Mitsunobu reaction of isoxazolin-5-one (4) with N-Boc-L- serine tert-butyl ester (5) and subsequent deprotection of the coupling product. Its structure was elucidated by spectroscopic analyses. The pharmacological activity of 1 was also examined with cloned glutamate receptors and transporters using a Xenopus oocyte-expressing system showing substrate activity on an excitatory amino acid carrier 1 (EAAC 1) as a glutamate transporter.
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(2001)
