Journal of the Chemical Society. Chemical communications p. 955 - 956 (1990)
Update date:2022-08-17
Topics:
Ashwell, Mark
Bleasdale, Christine
Golding, Bernard T.
O'Neill, Ian K.
2-Amino-6-chloropurines (2b)-(2e) react with trimethylamine/3-hydroxypropionitrile in the presence of 1,8-diazabicyclo<5.4.0>undec-7-ene to afford the corresponding N-9-substituted guanines (1b)-(1e) in near-quantitative yield.
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