2-difluoroMethylbenzoic acid

There total 7 articles about 2-difluoroMethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

Reference yield: 93.0%

1018678-48-2

methyl 5-phenyl-2-difluoromethylbenzoate

799814-32-7

2-(difluoromethyl)benzoic acid

Guidance literature:

With water; sodium hydroxide; for 0.5h; Reflux;

Reference yield: 87.0%

118-90-1

ortho-methylbenzoic acid

799814-32-7

2-(difluoromethyl)benzoic acid

Guidance literature:

With sodium persulfate; silver nitrate; Selectfluor; In water; acetonitrile; at 80 ℃; for 3h; Inert atmosphere; Schlenk technique; Cooling with liquid nitrogen;

DOI:10.1002/anie.201400225

Reference yield: 68.0%

C₂₆H₂₂O₂P⁽¹⁺⁾

799814-32-7

2-(difluoromethyl)benzoic acid

Guidance literature:

C₂₆H₂₂O₂P⁽¹⁺⁾; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at 45 ℃; for 12h; Inert atmosphere;

With water; potassium carbonate; In tetrahydrofuran; at 45 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00457